Home » 幹細胞治療 » 幹細胞能根治紅斑狼瘡

最近有究硏指出,紅斑狼瘡的病人身體內的幹細胞衰老速度比正常的細胞快。在身體中,幹細胞扮演重要的角色,血管的產生是
由幹細胞組織出來的,當幹細胞容易衰老血管便不完整,在紅斑狼瘡常見的問題便是血管的炎症。

血管是由幹細胞產生出來的,幹細胞形成血管內皮細胞和周細胞,幹細胞老化快了便不能產生完整的血管內皮。血管內皮不完整會產生血液的不正常凝固,血液不正常凝固便產生血管的炎症。

紅斑狼瘡的關節炎和腎炎同樣是由血管炎引起。

王啟元醫生

Clin Dev Immunol. 2013;2013:134243. doi: 10.1155/2013/134243. Epub 2013 Sep 16.
p53/p21 Pathway involved in mediating cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients.
Gu Z, Jiang J, Tan W, Xia Y, Cao H, Meng Y, Da Z, Liu H, Cheng C.
Author information
Abstract

Our and other groups have found that bone marrow-derived mesenchymal stem cells (BM-MSCs) from systemic lupus erythematosus (SLE) patients exhibited senescent behavior and are involved in the pathogenesis of SLE. Numerous studies have shown that activation of the p53/p21 pat hway inhibits the proliferation of BM-MSCs. The aim of this study was to determine whether p53/p21 pathway is involved in regulating the aging of BM-MSCs from SLE patients and the underlying mechanisms. We further confirmed that BM-MSCs from SLE patients showed characteristics of senescence. The expressions of p53 and p21 were significantly increased, whereas levels of Cyclin E, cyclin-dependent kinase-2, and phosphorylation of retinoblastoma protein were decreased in the BM-MSCs from SLE patients and knockdown of p21 expression reversed the senescent features of BM-MSCs from SLE patients. Our results demonstrated that p53/p21 pathway played a n important role in the senescence process of BM-MSCs from SLE.

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